SEL120-34A hydrochloride ( SEL 120-34A )

Catalog No. M12317 CAS No. 1609452-30-3

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Product Name

SEL120-34A hydrochloride
Note

Research use only, not for human use.
Brief Description

SEL120-34A is an ATP-competitive, selective, orally active CDK8 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively.
Description

SEL120-34A is an ATP-competitive, selective, orally active CDK8 inhibitor that inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50 of 4.4 nM and 10.4 nM, respectively; shows no significant inhibition on other members of the CDK family (200-fold over CDK9); inhibits phosphorylation of STAT1 S727 and STAT5 S726 in cancer cells, inhibits IFN- responsive genes expression in vitro; exhibits complete inhibitions of STAT1 S727 and STAT5 S726 in Colo-205 CRC xenograft tissues in mice (60mg/kg).
Synonyms

SEL 120-34A
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

1609452-30-3
Formula Weight

450.60
Molecular Formula

C15H19Br2ClN4
Purity

>98% (HPLC)
Solubility

DMSO : 62.5 mg/mL
SMILES

CC1=C2C3=C(CCCN3C(=N2)N4CCNCC4)C(=C1Br)Br.Cl
Chemical Name

7,8-Dibromo-9-methyl-2-piperazin-1-yl-5,6-dihydro-4H-imidazo[4,5,1-ij]quinoline hydrochloride

1. Rzymski T, et al. Oncotarget. 2017 May 16;8(20):33779-33795.

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